Maes L, Songa E B, Hamers R
Institute of Molecular Biology, Vrije Universiteit Brussel, St. Genesius-Rode, Belgium.
Acta Trop. 1993 Sep;54(3-4):261-9. doi: 10.1016/0001-706x(93)90098-v.
A new drug molecule (IMOL 881) was synthesized and is showing interesting trypanocidal properties. The test results on animal models indicate activity against several trypanosome species, both in the veterinary and in the human medicine application fields. The species tested so far include: T. evansi, T. equiperdum, T. gambiense and T. rhodesiense. The good activity combined with a relatively low toxicity results in a high therapeutic index (> 100). In addition to its curative properties, the drug also seems to exhibit a prophylactic potential, as evidenced by tests on drug treated mice, subsequently infected with T. evansi.
