Gouffier E, Garnier M, Turpin F, Coste T, Paraf A
Pathol Biol (Paris). 1976 Sep;24(7):463-7.
The authors report a case of major acanthocytosis which regressed spontaneously in a cirrhotic patient. The usual lipid abnormalities: considerable rise in free red cell cholesterol and lesser rise in phospholipid, regressed concommitantly to the disappearance of acanthocytes. No change in the main liver function tests was, however, observed. The etiological mechanisms of acanthocytosis in cirrhosis are probably multiple, and their interactions are compplex. The exchange of abnormal lipoproteins between the plasma and the red cell membrane is the last theory to be considered. On the other hand, no argument could explain the disappearance of the acanthocytosis, this phenomenon is considered up to now irreversible and a sign of the gravity of hepatic lesions.
作者报告了一例在肝硬化患者中自发消退的严重棘红细胞增多症病例。常见的脂质异常：游离红细胞胆固醇显著升高，磷脂升高幅度较小，随着棘红细胞的消失而同时消退。然而，主要肝功能检查未观察到变化。肝硬化中棘红细胞增多症的病因机制可能是多方面的，且它们之间的相互作用很复杂。血浆与红细胞膜之间异常脂蛋白的交换是最后要考虑的理论。另一方面，没有论据可以解释棘红细胞增多症的消失，到目前为止，这种现象被认为是不可逆的，是肝脏病变严重程度的一个标志。
