Changes in mammary glucose and protein uptake in relation to milk synthesis during lactation in high- and low-yielding goats.

1. Glucose and protein uptake were measured in both mammary glands of two low- and two high-yielding dairy goats during lactation. 2. Low-yielding goats tended to have higher arterial glucose concentrations, but approximately 40% lower arterio-venous differences (AV) and extraction rates (E) for glucose than high-yielding goats. 3. AV and E for glucose (but not protein) were linearly related to yields of both lactose, milk protein and fat. 4. Mammary uptake of glucose is determined primarily by mammary glucose metabolism, not glucose supply; lower intracellular glucose concentration in mammary cells of genetically superior animals thus explains the more efficient mammary uptake.