Sasa M, Komaki K, Tsuzuki H, Kamamura Y, Mori T, Miki H, Uyama T, Morimoto T, Monden Y
Second Department of Surgery, School of Medicine, University of Tokushima, Japan.
J Surg Oncol. 1993 Dec;54(4):255-9. doi: 10.1002/jso.2930540415.
Forty consecutive cases with invasive ductal carcinoma of the breast (samples of both the primary invasive area and the involved node were available for 19 cases, multiple sections of breast tissue including both the primary invasive area and forefront intraductal cancerous area were available for 15 cases; and multiple sections of breast cancerous tissue and the involved node were available for six cases) were examined by immunohistochemical analysis for evaluation of their proliferation rate. In this study, we selected the PCNA index as a marker of the proliferation rate of the tumor cells. We demonstrated that the PCNA index of the primary invasive area was significantly higher than that of the forefront intraductal area (P = 0.0017), and the PCNA index of the involved nodes was significantly higher than that of the primary invasive area (P = 0.0004). These preliminary findings suggest that the progression from the tumor cells of the intraductal cancerous area to the metastatic tumor cells must be accompanied by two phases of increase in the proliferation rate.
对40例连续性乳腺浸润性导管癌患者（19例患者可获得原发浸润区域和受累淋巴结的样本，15例患者可获得包括原发浸润区域和前沿导管内癌区域的多切片乳腺组织；6例患者可获得多切片癌组织和受累淋巴结）进行免疫组化分析，以评估其增殖率。在本研究中，我们选择增殖细胞核抗原（PCNA）指数作为肿瘤细胞增殖率的标志物。我们发现，原发浸润区域的PCNA指数显著高于前沿导管内区域（P = 0.0017），受累淋巴结的PCNA指数显著高于原发浸润区域（P = 0.0004）。这些初步研究结果表明，从导管内癌区域的肿瘤细胞进展为转移肿瘤细胞必须伴随着增殖率增加的两个阶段。
