Thiel G
Institute for Genetics, University of Cologne, Germany.
Brain Pathol. 1993 Jan;3(1):87-95. doi: 10.1111/j.1750-3639.1993.tb00729.x.
The nerve terminal of neurons is filled with small synaptic vesicles, specialized secretory organelles involved in the storage and release of neurotransmitters. The synapsins are a family of four proteins that are the major peripheral proteins on the cytoplasmic face of synaptic vesicles. Synaptophysin is the major integral membrane protein of synaptic vesicles. The characterization of the synapsins and of synaptophysin during the last years has revealed exciting information about their structure, regulation and possible function. To understand the role of the synapsins and synaptophysin in the biology of a nerve cell means to elucidate the fundamental mechanism of brain function, the release of neurotransmitter.
神经元的神经末梢充满了小突触小泡，这是参与神经递质储存和释放的特殊分泌细胞器。突触结合蛋白是一个由四种蛋白质组成的家族，是突触小泡胞质面的主要外周蛋白。突触素是突触小泡的主要整合膜蛋白。近年来对突触结合蛋白和突触素的特性研究揭示了有关它们的结构、调节及可能功能的令人兴奋的信息。了解突触结合蛋白和突触素在神经细胞生物学中的作用意味着要阐明脑功能的基本机制，即神经递质的释放。
