van den Pol A N
Section of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510.
J Biol Rhythms. 1993;8 Suppl:S11-5.
Glutamate and gamma-aminobutyrate (GABA) are two neurotransmitters that appear to play an important role in the hypothalamic suprachiasmatic nucleus (SCN) and in the adjacent areas of the medial hypothalamus. Converging evidence based on ultrastructural immunocytochemistry, molecular biology, calcium imaging, and electrophysiology suggests not only that GABA and glutamate are used for inhibitory and excitatory activity, respectively, in this region of the rat brain, but that these two fast-acting amino acids may account for the majority of neurotransmission there.
谷氨酸和γ-氨基丁酸（GABA）是两种神经递质，它们似乎在下丘脑视交叉上核（SCN）以及下丘脑内侧的相邻区域发挥重要作用。基于超微结构免疫细胞化学、分子生物学、钙成像和电生理学的综合证据表明，在大鼠大脑的这个区域，GABA和谷氨酸不仅分别用于抑制性和兴奋性活动，而且这两种快速作用的氨基酸可能占该区域神经传递的大部分。
