Thibaut F, Colonna L
S.H.U. du Pr Colonna, C.H.S. du Rouvray, Sotteville-les-Rouen.
Encephale. 1993 May-Jun;19(3):263-7.
Since the first report in 1977, many studies have reported the efficacy of beta blockers for the treatment of violent and aggressive behavior. Propranolol had mainly been reported to be effective in aggressive patients with organic brain syndromes of diverse etiologies. Doses of propranolol had varied ranging from 60 to 1,440 mg per day with means also varying from 250 to 400 mg per day. Propranolol was in most cases added to existing neuroleptic treatment but sometimes it had been the only medication used. Treatment response required 4 to 6 weeks of maintenance therapeutic doses. The utility of propranolol in aggressive patients with other diagnoses and the efficacy of other beta blockers remain unclear and require further studies.
自1977年首次报告以来，许多研究都报道了β受体阻滞剂治疗暴力和攻击行为的疗效。主要有报告称普萘洛尔对患有多种病因的器质性脑综合征的攻击性患者有效。普萘洛尔的剂量从每天60毫克到1440毫克不等，平均剂量也从每天250毫克到400毫克不等。在大多数情况下，普萘洛尔是添加到现有的抗精神病药物治疗中，但有时它是唯一使用的药物。治疗反应需要4至6周的维持治疗剂量。普萘洛尔在患有其他诊断的攻击性患者中的效用以及其他β受体阻滞剂的疗效仍不明确，需要进一步研究。
