去甲替林的抗抑郁作用与血浆水平之间的关系。临床研究。
Relationship between antidepressant effect and plasma level of nortriptyline. Clinical studies.
作者信息
Kragh-Søorensen P, Hansen C E, Baastrup P C
出版信息
Pharmakopsychiatr Neuropsychopharmakol. 1976 Jan;9(1):27-32. doi: 10.1055/s-0028-1094474.
PMID:790409
Abstract
Strong evidence has been found for the assumption that NT inhibits its own antidepressive effect at high, but non toxic plasma levels in patients suffering from endogenous depression. Based on three investigations we will recommend an optimal therapeutic plasma range for NT between 50 and 150 ng NT/ml.
摘要
已有强有力的证据支持这样一种假设
在患有内源性抑郁症的患者中，当血浆水平处于较高但无毒的水平时，去甲替林（NT）会抑制其自身的抗抑郁作用。基于三项研究，我们将推荐去甲替林的最佳治疗血浆范围为50至150纳克去甲替林/毫升。
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