Ahnert-Hilger G, Grube K, Kvols L, Lee I, Mönch E, Riecken E O, Schmitt L, Wiedenmann B
Department of Internal Medicine, Universitätsklinikum Steglitz, Free University of Berlin, Germany.
Eur J Cancer. 1993;29A(14):1982-4. doi: 10.1016/0959-8049(93)90458-r.
Human neuroendocrine tumours of the gastroenteropancreatic system contain major integral membrane proteins of small synaptic vesicles of neurons, together with characteristic membrane polypeptides of large dense-core vesicles of neurons and neuroendocrine cells. The membrane polypeptides characteristic for small synaptic and large dense-core vesicles are detected in pheochromocytomas (n = 6), functional (n = 6) and non-functional (n = 6) foregut, and midgut carcinoids (n = 17). All gastroenteropancreatic tumours contain large amounts of amino acid neurotransmitters, i.e. glycine and glutamate. gamma-Aminobutyric acid, however, is only found in some foregut carcinoids. Thus, neuroendocrine gastroenteropancreatic tumours possess a vesicle type with a content and membrane composition similar to small synaptic vesicles of neurons.
胃肠胰系统的人类神经内分泌肿瘤含有神经元小突触囊泡的主要整合膜蛋白，以及神经元和神经内分泌细胞大致密核心囊泡的特征性膜多肽。在嗜铬细胞瘤（n = 6）、功能性（n = 6）和非功能性（n = 6）的前肠以及中肠类癌（n = 17）中检测到了小突触囊泡和大致密核心囊泡特有的膜多肽。所有胃肠胰肿瘤都含有大量氨基酸神经递质，即甘氨酸和谷氨酸。然而，γ-氨基丁酸仅在一些前肠类癌中发现。因此，神经内分泌胃肠胰肿瘤具有一种囊泡类型，其内容物和膜组成与神经元的小突触囊泡相似。
