免疫球蛋白轻链恒定区和可变区多态性（Cκ、VκII、VλVII和VHIII）与类风湿性关节炎之间缺乏相关性。
Lack of association between immunoglobulin light-chain constant- and variable-region polymorphisms (C kappa, V kappa II, V lambda VII and VHIII) and rheumatoid arthritis.
作者信息
Sidebottom D, Bate A S, Grennan D M
机构信息
Rheumatic Diseases Centre, Hope Hospital, Salford, UK.
出版信息
Exp Clin Immunogenet. 1993;10(3):129-36.
PMID:7904455
Abstract
Restriction fragment length polymorphisms (RFLPs) of C kappa, V kappa II, V lambda VII and VHIII genes were studied from a pool of 104 subjects with rheumatoid arthritis and 96 controls. There were no overall associations with either rheumatoid arthritis itself, or with HLA-DR4-positive and DR4-negative RA subgroups within rheumatoid subjects in this UK Caucasoid population.
摘要
对104名类风湿性关节炎患者和96名对照者的样本研究了Cκ、VκII、VλVII和VHIII基因的限制性片段长度多态性（RFLP）。在这个英国白种人群体中，这些多态性与类风湿性关节炎本身，或类风湿性关节炎患者中HLA - DR4阳性和DR4阴性的类风湿性关节炎亚组均无总体关联。
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