The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat.

作者信息

Lambert P D, Wilding J P, al-Dokhayel A A, Gilbey S G, Bloom S R

机构信息

Division of Endocrinology and Metabolism, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

出版信息

Brain Res. 1993 Nov 26;629(1):146-8. doi: 10.1016/0006-8993(93)90493-7.

Neuropeptide Y (NPY) and the endogenous kappa-opioid receptor ligand, dynorphin (dyn), stimulate feeding when injected centrally in the rat. Norbinaltorphimine (norBNI, 25 nmol) reduced the feeding response to NPY (2.4 nmol) by 67% (P < 0.02). An additive effect of dynorphin and NPY was seen on food intake (saline 0.8 +/- 0.1, dyn 1.9 +/- 0.4, NPY 6.1 +/- 1.4, dyn and NPY 9.7 +/- 2.2). A component of NPY-induced feeding may be mediated by kappa-opioid neuronal systems.