大肠杆菌Dga（MurI）蛋白与戊糖片球菌谷氨酸消旋酶具有生物活性和结构域。
The Escherichia coli Dga (MurI) protein shares biological activity and structural domains with the Pediococcus pentosaceus glutamate racemase.
作者信息
Pucci M J, Novotny J, Discotto L F, Dougherty T J
机构信息
Department of Microbiology, Bristol-Myers Squibb Research Institute, Wallingford, Connecticut 06492-7660.
出版信息
J Bacteriol. 1994 Jan;176(2):528-30. doi: 10.1128/jb.176.2.528-530.1994.
Abstract
The Pediococcus pentosaceus glutamate racemase gene product complemented the D-glutamate auxotrophy of Escherichia coli WM335. Amino acid sequence analysis of the two proteins revealed 28% identity, primarily in six clusters scattered throughout the sequence. Further analyses indicated secondary structure similarities between the two proteins. These data support a recent report that the dga (murI) gene product is a glutamate racemase.
摘要
戊糖片球菌谷氨酸消旋酶基因产物补充了大肠杆菌WM335的D-谷氨酸营养缺陷型。对这两种蛋白质的氨基酸序列分析显示有28%的同一性，主要集中在整个序列中分散的六个簇中。进一步分析表明这两种蛋白质之间存在二级结构相似性。这些数据支持了最近一份关于dga（murI）基因产物是一种谷氨酸消旋酶的报告。
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本文引用的文献
1
The biosynthesis of D-amino acids in Bacillus licheniformis.地衣芽孢杆菌中D-氨基酸的生物合成
Biochim Biophys Acta. 1962 Jul 30;62:114-21. doi: 10.1016/0006-3002(62)90496-1.
2
Transamination of D-amino acids by Bacillus subtilis.枯草芽孢杆菌对D-氨基酸的转氨作用。
J Bacteriol. 1955 Mar;69(3):357-62. doi: 10.1128/jb.69.3.357-362.1955.
3
D-Amino acid transamination in bacillus anthracis.炭疽芽孢杆菌中的D-氨基酸转氨作用
J Bacteriol. 1955 Oct;70(4):420-6. doi: 10.1128/jb.70.4.420-426.1955.
4
Purification, cloning, and cofactor independence of glutamate racemase from Lactobacillus.来自乳酸杆菌的谷氨酸消旋酶的纯化、克隆及辅因子非依赖性
Biochemistry. 1993 Apr 20;32(15):3981-90. doi: 10.1021/bi00066a019.
5
The murI gene of Escherichia coli is an essential gene that encodes a glutamate racemase activity.大肠杆菌的murI基因是一个编码谷氨酸消旋酶活性的必需基因。
J Bacteriol. 1993 May;175(10):2970-9. doi: 10.1128/jb.175.10.2970-2979.1993.
6
Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase.谷氨酸消旋酶催化反应中的同位素效应及催化残基的鉴定
Biochemistry. 1993 Apr 20;32(15):3998-4006. doi: 10.1021/bi00066a021.
7
Mechanism of the reaction catalyzed by glutamate racemase.谷氨酸消旋酶催化反应的机制。
Biochemistry. 1993 Apr 20;32(15):3991-7. doi: 10.1021/bi00066a020.
8
The Escherichia coli mutant requiring D-glutamic acid is the result of mutations in two distinct genetic loci.需要D-谷氨酸的大肠杆菌突变体是两个不同基因位点发生突变的结果。
J Bacteriol. 1993 Jan;175(1):111-6. doi: 10.1128/jb.175.1.111-116.1993.
9
A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens.一个从核苷酸序列数据预测蛋白质二级结构的程序：应用于组织相容性抗原。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):243-55. doi: 10.1093/nar/12.1part1.243.
10
Properties of a D-glutamic acid-requiring mutant of Escherichia coli.大肠杆菌一种需要D-谷氨酸的突变体的特性
J Bacteriol. 1973 May;114(2):499-506. doi: 10.1128/jb.114.2.499-506.1973.
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