溶剂/去污剂处理的抗血友病因子浓缩物中的B19细小病毒DNA

B19 parvovirus DNA in solvent/detergent-treated anti-haemophilia concentrates.

作者信息

Lefrère J J, Mariotti M, Thauvin M

机构信息

Institut National de Transfusion Sanguine, Hôpital Saint-Antoine, Paris, France.

出版信息

Lancet. 1994 Jan 22;343(8891):211-2. doi: 10.1016/s0140-6736(94)90993-8.

DOI:10.1016/s0140-6736(94)90993-8

PMID:7904670

Abstract

A transfusional B19 parvovirus infection may have severe consequences in immunocompromised hosts. The presence of B19 DNA was investigated with a polymerase chain reaction (PCR) assay in 30 batches of solvent/detergent-treated clotting factor concentrates (12 batches of factor VIII, 16 batches of factor IX, 1 batch of factor VII, and 1 batch of PPSB). B19 DNA was detected in 6 (20%) batches, including 3 factor VIII and 3 factor IX concentrates. Because of the frequency of B19 DNA in batches of clotting factors, measures to prevent transfusional risk of B19 infection via these blood products are justified, especially in recipients immunocompromised by HIV infection.

摘要

输血传播的B19细小病毒感染在免疫功能低下的宿主中可能会产生严重后果。采用聚合酶链反应（PCR）分析法对30批经溶剂/去污剂处理的凝血因子浓缩物（12批凝血因子VIII、16批凝血因子IX、1批凝血因子VII和1批人凝血酶原复合物）进行了B19 DNA检测。在6批（20%）样本中检测到B19 DNA，其中包括3批凝血因子VIII浓缩物和3批凝血因子IX浓缩物。鉴于凝血因子批次中B19 DNA的出现频率，采取措施预防通过这些血液制品发生B19感染的输血风险是合理的，尤其是在因感染HIV而免疫功能低下的受血者中。