Sánchez-Prieto J, Herrero I, Miras-Portugal M T, Mora F
Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
Brain Res Bull. 1994;33(3):357-9. doi: 10.1016/0361-9230(94)90206-2.
The Ca(2+)-dependent release of glutamate induced by 4-aminopyridine in synaptosomes prepared both from the cerebral cortex and basal ganglia was unchanged in aged rats (27-30 months) when compared to adults rats (3 months). Consistent with the absence of changes in glutamate exocytosis during aging, the rise in the cytosolic free Ca2+ concentration, [Ca2+]c, induced by depolarization in synaptosomes from aged rats was similar to that found in control adult rats. The results suggest that during aging the nerve terminals from the cerebral cortex and basal ganglia maintain an intact ability to release glutamate by exocytosis.
与成年大鼠（3个月）相比，4-氨基吡啶诱导的来自大脑皮层和基底神经节的突触体中谷氨酸的钙依赖性释放，在老年大鼠（27-30个月）中没有变化。与衰老过程中谷氨酸胞吐作用没有变化一致，老年大鼠突触体去极化诱导的胞质游离钙浓度[Ca2+]c的升高与对照成年大鼠相似。结果表明，在衰老过程中，大脑皮层和基底神经节的神经末梢通过胞吐作用释放谷氨酸的能力保持完整。
