氯化物和二酰胺对八种哺乳动物血清血管紧张素I转换酶活性的影响。
Effect of chloride and diamide on serum angiotensin I-converting enzyme activity from eight mammalian species.
作者信息
Ibarra-Rubio M E, Gómez-Velez L A, Cruz C, Pedraza-Chaverrí J
机构信息
Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de la Nutrición, Salvador Zubirán, Tlalpan, D. F., México.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Oct;106(2):495-501. doi: 10.1016/0742-8413(93)90169-l.
PMID:7904922
Abstract
- The effect of chloride on serum angiotensin I-converting enzyme (ACE) activity was characterized in eight mammalian species: dog, guinea pig, hamster, human, mouse, rabbit, rat, and sheep. 2. Optimum chloride concentrations varied from 300 mM for rabbit to 1700 mM for hamster. 3. The increments with these optimum concentrations with respect to 100 mM chloride concentration were from 1.4-fold in rabbit to 7.9-fold in hamster and dog. 4. There was no correlation between serum chloride concentration or serum ACE activity and optimum chloride concentration. 5. Serum ACE increased only in humans with diamide pretreatment suggesting the presence of endogenous inhibitors.
摘要
- 在狗、豚鼠、仓鼠、人、小鼠、兔子、大鼠和绵羊这八种哺乳动物中研究了氯离子对血清血管紧张素I转换酶（ACE）活性的影响。2. 最佳氯离子浓度从兔子的300 mM到仓鼠的1700 mM不等。3. 相对于100 mM氯离子浓度，这些最佳浓度下的增量从兔子的1.4倍到仓鼠和狗的7.9倍。4. 血清氯离子浓度或血清ACE活性与最佳氯离子浓度之间没有相关性。5. 只有在接受二酰胺预处理的人中血清ACE才会增加，这表明存在内源性抑制剂。
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