Aliot E, Sadoul N, De Chillou C
Service de Cardiologie, Hôpital Central, Nancy, France.
Eur Heart J. 1993 Nov;14 Suppl H:74-7. doi: 10.1093/eurheartj/14.suppl_h.74.
It is only in the last few years that the broad-spectrum antiarrhythmic properties of sotalol have become increasingly recognized. Racemic sotalol has potent beta-blocking and class III antiarrhythmic properties, and it has been reported that this drug is able to control supraventricular and ventricular arrhythmias. Recently, several studies performed with the d-sotalol isomer, which is almost devoid of the beta-blocking effects compared to the racemate, suggest significant antiarrhythmic efficacy and good tolerance of the dextro-isomer. In this paper we review and discuss the effects of sotalol and d-sotalol in patients with ventricular tachycardia (VT), ventricular fibrillation (VF) or cardiac arrest in whom VT or VF was induced by programmed electrical stimulation (PES).
直到最近几年，索他洛尔的广谱抗心律失常特性才越来越受到认可。消旋索他洛尔具有强效的β受体阻滞作用和Ⅲ类抗心律失常特性，据报道该药物能够控制室上性和室性心律失常。最近，几项使用d-索他洛尔异构体进行的研究表明，与消旋体相比，d-索他洛尔异构体几乎没有β受体阻滞作用，但具有显著的抗心律失常疗效和良好的耐受性。在本文中，我们回顾并讨论了索他洛尔和d-索他洛尔对室性心动过速（VT）、室颤（VF）或心脏骤停患者（这些患者的VT或VF由程序电刺激（PES）诱发）的影响。
