Arletti R, Benelli A, Mazzaferro M, Calzà L, Giardino L, Bertolini A
Institute of Pharmacology, University of Modena, Italy.
Horm Behav. 1993 Dec;27(4):499-510. doi: 10.1006/hbeh.1993.1036.
The effect of oxytocin on feeding, drinking, and male copulatory behavior was studied in rats neonatally injected with monosodium glutamate (MSG), a treatment that destroys neuronal perikarya of the arcuate nucleus and depletes the brain of proopiomelanocortin-derived peptides (melanocortins, endorphins). Both oxytocin-induced inhibition of feeding (1 and 10 micrograms/rat ICV and 150 micrograms/rat IP) and drinking (75 and 150 micrograms/rat IP) and oxytocin-induced improvement of male copulatory behavior (200 ng/rat IP) were either unaffected or in fact increased by neonatal MSG treatment. These data suggest that oxytocin neither inhibits feeding and drinking nor improves male sexual behavior through the release of melanocortin peptide(s) in the brain.
研究了催产素对新生期注射味精（MSG）的大鼠进食、饮水及雄性交配行为的影响，MSG处理会破坏弓状核的神经元胞体并使脑中阿片促黑素细胞皮质素衍生肽（黑素皮质素、内啡肽）耗竭。无论是催产素诱导的进食抑制（1和10微克/大鼠脑室内注射及150微克/大鼠腹腔注射）、饮水抑制（75和150微克/大鼠腹腔注射），还是催产素诱导的雄性交配行为改善（200纳克/大鼠腹腔注射），均未受新生期MSG处理的影响，实际上有的还增强了。这些数据表明，催产素并非通过释放脑中的黑素皮质素肽来抑制进食和饮水，也不能改善雄性性行为。
