Roberts M M, To L B, Gillis D, Mundy J, Rawling C, Ng K, Juttner C A
Haematology Department, Institute of Medical and Veterinary Science, Adelaide, Australia.
Bone Marrow Transplant. 1993 Nov;12(5):469-75.
The rate and pattern of recovery of total lymphocytes, T cell subsets, B cells and NK cells were compared for 12 months following recovery phase peripheral blood stem cell (PBSC) autotransplantation (n = 49), autologous (n = 7) and allogeneic BMT (n = 11). The PBSC group had a significantly faster recovery of total lymphocyte count, total T cells (CD3+ cells), CD8 cells and CD4 cells than the allogeneic BMT group. The pattern of earlier recovery of CD8 cells than CD4 cells was the same for each type of transplant. Reconstitution following autologous BMT was intermediate between PBSC and allogeneic BMT. Multivariate analysis identified type of transplant, number of mononuclear cells transplanted and conditioning regimen as significantly influencing immune recovery.
对49例接受缓解期外周血干细胞（PBSC）自体移植、7例接受自体移植以及11例接受异基因骨髓移植（BMT）后的患者，比较了12个月内总淋巴细胞、T细胞亚群、B细胞和NK细胞的恢复速率和模式。PBSC组总淋巴细胞计数、总T细胞（CD3+细胞）、CD8细胞和CD4细胞的恢复明显快于异基因BMT组。每种移植类型中，CD8细胞比CD4细胞更早恢复的模式相同。自体BMT后的重建情况介于PBSC和异基因BMT之间。多变量分析确定移植类型、移植的单个核细胞数量和预处理方案对免疫恢复有显著影响。
