Helton T E, Daunais J B, McGinty J F
Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Brain Res Mol Brain Res. 1993 Nov;20(3):285-8. doi: 10.1016/0169-328x(93)90054-s.
Rats were treated with escalating doses of cocaine until they experienced a convulsion and were euthanized 1 or 3 h after the last injection. Quantitative in situ hybridization histochemistry revealed that c-fos and zif/268 mRNAs were induced at 1 h in many limbic structures and declined 3 h after cocaine-induced convulsions. Preprodynorphin and preproenkephalin signals increased in many of the same structures 3 h, but not 1 h, after cocaine-induced convulsions.
给大鼠注射递增剂量的可卡因，直至其出现惊厥，并在最后一次注射后1小时或3小时实施安乐死。定量原位杂交组织化学显示，在许多边缘系统结构中，c-fos和zif/268 mRNA在1小时时被诱导表达，并在可卡因诱发惊厥后3小时下降。前强啡肽原和前脑啡肽原信号在可卡因诱发惊厥后3小时而非1小时在许多相同结构中增加。
