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[The neuropeptide PACAP: its presence, its mode of action and its receptors].

作者信息

Christophe J

机构信息

Laboratoire de Chimie biologique et de la nutrition, faculté de Médecine de l'Université libre de Bruxelles.

出版信息

Bull Mem Acad R Med Belg. 1993;148(3-4):188-93.

PMID:7906174
Abstract

Specific PACAP type I receptors show 200- 1000-fold higher affinity for both PACAPS as compared to VIP. Their occupancy stimulates adenylate cyclase and frequently also the inositol phosphate-calcium cascade. Considering a few PACAP-38 and PACAP-27 effects exerted on the hypothalamo-hypophyseal axis and elsewhere, there appears already that these neuropeptides may play a physiological role even more important than that of VIP.

摘要

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