Nilsson L, Mohammed A K, Henriksson B G, Folkesson R, Winblad B, Bergström L
Karolinska Institute, Department of Geriatric Medicine, Huddinge University Hospital, Sweden.
Brain Res. 1993 Nov 19;628(1-2):93-8. doi: 10.1016/0006-8993(93)90942-g.
In the present study we have quantified preprosomatostatin-mRNA and somatostatin levels in rat brain following environmental stimulation. Animals were housed for 30 days in an enriched or impoverished environment prior to analysis. After 30 days of housing half of the rats from each environment were behaviourally tested for 3 days. Housing in enriched environment improved performance in a spatial learning situation. The open-field behaviour of these animals was characterized by initially higher rearing scores and a more rapid habituation to novel environment as measured by spontaneous locomotor activity. We found significantly elevated somatostatin levels in the cortex following enriched environment, compared with impoverished environment. Exposure to behavioural testing of impoverished animals led to increased cortical somatostatin levels. Hypothalamic somatostatin levels increased significantly after housing in enriched environment, while the testing procedure had no influence. Our data shows that the somatostatin system in the rat brain was activated in association with cognitive changes, that were induced by housing in an enriched environment.
在本研究中，我们对环境刺激后大鼠脑中前促生长抑素原mRNA和生长抑素水平进行了定量分析。在分析之前，将动物置于丰富或贫乏环境中饲养30天。在每种环境中饲养30天后，将一半的大鼠进行为期3天的行为测试。饲养在丰富环境中的大鼠在空间学习任务中的表现有所改善。这些动物在旷场实验中的行为表现为，最初的直立得分较高，并且通过自发运动活动测量，它们对新环境的适应速度更快。我们发现，与贫乏环境相比，丰富环境饲养后大鼠皮层中的生长抑素水平显著升高。对贫乏环境饲养的动物进行行为测试会导致皮层生长抑素水平升高。在丰富环境中饲养后，下丘脑生长抑素水平显著增加，而测试过程对此没有影响。我们的数据表明，大鼠脑中的生长抑素系统与丰富环境饲养所诱导的认知变化相关联而被激活。
