Surmeier D J, Kitai S T
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee at Memphis 38163.
Prog Brain Res. 1993;99:309-24. doi: 10.1016/s0079-6123(08)61354-0.
The potassium and sodium currents in acutely isolated neostriatal neurons are modulated by activation of both D1- and D2-class receptors. The amplification of mRNA in individual neurons supports this conclusion and has shown that striatonigral neurons express not only D1 and D2 receptors, but D3 receptors as well. The characteristics of the modulations produced by these receptors provide a foundation for both antagonistic and synergistic actions of D1 and D2 agonists in the neostriatum. Understanding precisely how these modulations interact in shaping excitability, however, will require a better characterization of spatial domains in which they operate.
急性分离的新纹状体神经元中的钾离子和钠离子电流受到 D1 类和 D2 类受体激活的调节。单个神经元中 mRNA 的扩增支持了这一结论，并表明纹状体黑质神经元不仅表达 D1 和 D2 受体，还表达 D3 受体。这些受体产生的调节特性为 D1 和 D2 激动剂在新纹状体中的拮抗和协同作用提供了基础。然而，要准确理解这些调节如何相互作用以塑造兴奋性，将需要更好地表征它们发挥作用的空间域。
