Ghosh N, Chattopadhyay U
Department of Tumour-Immumobiology, Chittaranjan National Cancer Institute, Calcutta, India.
In Vivo. 1993 Sep-Oct;7(5):435-40.
The natural killer (NK) cell activity and PHA-induced mitogenesis of the peripheral blood mononuclear cells (PBMC) were assessed in a group of schizophrenic patients treated with phenothiazines and haloperidol for different lengths of time. Significantly higher levels of NK cytotoxicity and lymphocyte mitogenesis were observed in the patients as compared to those in age and sex-matched healthy volunteers. Enhancement of NK activity in the patients depended on the duration and continuity of treatment with these calmodulin antagonists. Increased susceptibility to chlorpromazine (CPZ, a phenothiazine derivative)-induced in vitro inhibition of basal and mitogen stimulated tritiated thymidine incorporation was observed in the patients' lymphocytes, though the reversibility of CPZ binding was similar in these cells and in normal PBMC. The data suggested that continuous in vivo exposure to phenothiazines and haloperidol resulted in stimulation of lymphocyte activity. The enhanced lymphocyte activity following treatment with calmodulin antagonists may be associated with the antineoplastic activity of these drugs.
对一组接受不同时长吩噻嗪类药物和氟哌啶醇治疗的精神分裂症患者外周血单个核细胞（PBMC）的自然杀伤（NK）细胞活性和PHA诱导的有丝分裂进行了评估。与年龄和性别匹配的健康志愿者相比，患者的NK细胞毒性和淋巴细胞有丝分裂水平显著更高。患者NK活性的增强取决于这些钙调蛋白拮抗剂的治疗时长和连续性。在患者淋巴细胞中观察到对氯丙嗪（CPZ，一种吩噻嗪衍生物）诱导的体外抑制基础和有丝分裂原刺激的氚标记胸腺嘧啶核苷掺入的敏感性增加，尽管这些细胞和正常PBMC中CPZ结合的可逆性相似。数据表明，体内持续暴露于吩噻嗪类药物和氟哌啶醇会导致淋巴细胞活性受到刺激。用钙调蛋白拮抗剂治疗后淋巴细胞活性增强可能与这些药物的抗肿瘤活性有关。
