新型限制性片段长度多态性（RFLPs）和微卫星重复序列增加了定位于Xq22 - q25的四个基因座的信息含量。

Novel RFLPs and microsatellite repeats increase informativity at four loci mapping to Xq22-q25.

作者信息

Newton R, Stanier P, Forbes S, Moore G E

机构信息

Action Research Laboratory for the Molecular Biology of Fetal Development, Queen Charlotte's and Chelsea Hospital, London, UK.

出版信息

Hum Genet. 1994 Feb;93(2):218-21. doi: 10.1007/BF00210618.

DOI:10.1007/BF00210618

PMID:7906669

Abstract

Three microsatellites and five restriction fragment length polymorphisms (RFLPs) have been detected at loci DXS275, DXS97, DXS11 and DXS100. All of the reported polymorphisms are in linkage equilibrium with existing polymorphisms at these loci. However, two RFLPs at DXS275 and two at DXS97 appear to be in linkage disequilibrium with each other. Increased informativity at these loci have enabled exclusion of Xq22-q25 as a candidate region for X-linked spina bifida and anencephaly, and should aid in the mapping of other genes in the region.

摘要

在DXS275、DXS97、DXS11和DXS100位点检测到三个微卫星和五个限制性片段长度多态性（RFLP）。所有报道的多态性与这些位点现有的多态性处于连锁平衡状态。然而，DXS275的两个RFLP和DXS97的两个RFLP似乎彼此处于连锁不平衡状态。这些位点信息性的增加使得排除Xq22 - q25作为X连锁脊柱裂和无脑畸形的候选区域成为可能，并且应该有助于该区域其他基因的定位。