Maione S, D'Amico M, Berrino L, Filippelli A, Leyva J, Rossi F
Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, II University of Naples, Italy.
Eur J Pharmacol. 1993 Nov 30;250(1):209-12. doi: 10.1016/0014-2999(93)90647-z.
We investigated the behavioural effects induced by endothelin-1 injected into the lateral-caudal periaqueductal gray matter of freely moving rats. Endothelin-1 induced a dose-dependent longitudinal rolling of the body (barrel rolling) which was prevented by D,L-2-amino-5-phosphonovalerate (2-APV), an N-methyl-D-aspartate (NMDA) receptor antagonist, but not by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-NMDA receptor antagonist. This effect, not reproducible with NMDA alone, indicates that the activation of the NMDA receptors in the periaqueductal gray area may be a necessary, but not sufficient, step for the triggering of endothelin-1-induced barrel-rolling behaviour.
我们研究了向自由活动大鼠的尾侧导水管周围灰质外侧注射内皮素-1所诱导的行为效应。内皮素-1会诱导身体呈剂量依赖性的纵向翻滚（桶状翻滚），N-甲基-D-天冬氨酸（NMDA）受体拮抗剂D,L-2-氨基-5-磷酸戊酸（2-APV）可阻止这种现象，但非NMDA受体拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮（CNQX）则不能。单独使用NMDA无法重现这种效应，这表明导水管周围灰质区域中NMDA受体的激活可能是触发内皮素-1诱导的桶状翻滚行为的必要但不充分步骤。
