Tomaru A, Ishii A, Kishibayashi N, Karasawa A
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Jpn J Pharmacol. 1993 Dec;63(4):525-8. doi: 10.1254/jjp.63.525.
Colonic motility was measured with three catheter pressure transducers that were inserted into the descending colon at the distance of 4 cm, 6 cm and 8 cm from the anal verge in anesthetized rats. Colonic infusion of glycerol (65%, 2 ml/kg) induced large phasic pressure changes with high amplitude and long duration. Some of the pressure changes propagated over all the three recording sites, appearing to be equivalent to giant migrating contractions. These glycerol-induced large propulsions were abolished by lidocaine (5%, 2 ml/kg, intracolon), hexamethonium (10 mg/kg, i.v.) or clonidine (30 micrograms/kg, i.v.); and they were almost entirely suppressed by atropine (3 mg/kg, i.v.), suggesting the principal involvement of the cholinergic neural pathway.
在麻醉大鼠中，通过三个导管压力换能器测量结肠动力，这些换能器插入距肛门边缘4厘米、6厘米和8厘米处的降结肠。结肠内注入甘油（65%，2毫升/千克）可诱导出高振幅、持续时间长的大幅度相性压力变化。一些压力变化在所有三个记录部位传播，似乎等同于巨大移行性收缩。这些甘油诱导的大推进运动可被利多卡因（5%，2毫升/千克，结肠内给药）、六甲铵（10毫克/千克，静脉注射）或可乐定（30微克/千克，静脉注射）消除；并且它们几乎完全被阿托品（3毫克/千克，静脉注射）抑制，提示胆碱能神经通路起主要作用。
