Chung K, Kim H J, Na H S, Park M J, Chung J M
School of Allied Health Sciences, University of Texas Medical Branch, Galveston 77555-0843.
Neurosci Lett. 1993 Nov 12;162(1-2):85-8. doi: 10.1016/0304-3940(93)90566-4.
Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after a tight ligation of the L5 spinal nerve, putative sympathetic postganglionic fibers were examined in the injured spinal nerve and the dorsal root ganglion (DRG), using immunohistochemical staining with antibody against tyrosine hydroxylase (TH). In the neuropathic rats, there was an increase in the number of TH-immunolabeled fibers in the spinal nerve, and some DRG cells were surrounded by the labeled fibers. These abnormalities of sympathetic postganglionic innervation of the injured spinal nerve or the DRG may be a part of the mechanisms underlying the development of SMP.
利用我们所建立的大鼠模型，对交感神经维持性神经病理性疼痛（SMP）的潜在潜在机制进行了探索。在L5脊神经紧密结扎后出现神经病理性疼痛行为的大鼠中，使用抗酪氨酸羟化酶（TH）抗体进行免疫组织化学染色，在损伤的脊神经和背根神经节（DRG）中检查假定的交感神经节后纤维。在神经病理性大鼠中，脊神经中TH免疫标记纤维的数量增加，并且一些DRG细胞被标记纤维包围。损伤的脊神经或DRG的交感神经节后神经支配的这些异常可能是SMP发生机制的一部分。
