Motojima K, Furui J, Kohara N, Izawa K, Kanematsu T, Shiku H
Second Department of Surgery, Nagasaki University School of Medicine, Japan.
Surgery. 1994 Mar;115(3):349-54.
Correlation between erbB-2 expression, histologic type of gastric carcinoma, and survival after curative resection was evaluated.
Paraffin-embedded specimens from 120 patients who underwent curative resection of gastric carcinoma were analyzed immunohistochemically for the expression of erbB-2.
Enhanced erbB-2 expression correlated with tumor stage and depth of invasion. Well-differentiated adenocarcinomas had a higher incidence of erbB-2 expression than did poorly differentiated carcinomas. Survival rates of 33 patients with erbB-2-positive carcinomas were significantly lower than those of 87 with erbB-2-negative carcinomas (p < 0.001). Survival rates of patients with well-differentiated adenocarcinomas that were erbB-2 positive were significantly lower than those that were erbB-2 negative (p < 0.001). However, the presence of erbB-2 was not associated with altered survival in 46 patients with poorly differentiated carcinomas. Multivariate analysis of all 120 patients revealed that independent predictors of recurrent disease include nodal involvement (p = 0.003) and erbB-2 expression (p = 0.0051).
Our results suggest that erbB-2 expression is a new marker associated with poor prognosis in well-differentiated gastric adenocarcinomas.
评估了erbB-2表达、胃癌组织学类型与根治性切除术后生存率之间的相关性。
对120例行胃癌根治性切除术患者的石蜡包埋标本进行免疫组织化学分析，以检测erbB-2的表达。
erbB-2表达增强与肿瘤分期和浸润深度相关。高分化腺癌中erbB-2表达的发生率高于低分化癌。33例erbB-2阳性癌患者的生存率显著低于87例erbB-2阴性癌患者（p<0.001）。erbB-2阳性的高分化腺癌患者的生存率显著低于erbB-2阴性患者（p<0.001）。然而，46例低分化癌患者中erbB-2的存在与生存率改变无关。对所有120例患者进行多变量分析显示，复发疾病的独立预测因素包括淋巴结受累（p = 0.003）和erbB-2表达（p = 0.0051）。
我们的结果表明，erbB-2表达是高分化胃腺癌预后不良的一个新标志物。
