Gent A E, Hellier M D, Grace R H, Swarbrick E T, Coggon D
Salisbury District Hospital, Odstock, Wiltshire, UK.
Lancet. 1994 Mar 26;343(8900):766-7. doi: 10.1016/s0140-6736(94)91841-4.
To test the hypothesis that Crohn's disease is caused by delayed exposure to enteric infections, we did a case-control study. We compared 133 patients who have Crohn's disease and 231 with ulcerative colitis who have controls selected from the general population and matched for age and sex. Crohn's disease was more common in subjects whose first houses had a hot-water tap (odds ratio 5.0, 95% CI 1.4-17.3) and separate bathroom (3.3, 1.3-8.3). Ulcerative colitis showed no clear relation to household amenities in infancy. These findings may explain why the incidence of Crohn's disease has increased in developed countries over the past 50 years.
为了验证克罗恩病是由肠道感染暴露延迟所致这一假说，我们开展了一项病例对照研究。我们比较了133例克罗恩病患者以及231例溃疡性结肠炎患者，后者的对照从普通人群中选取，并在年龄和性别上进行了匹配。在首个住所设有热水龙头的受试者中，克罗恩病更为常见（比值比5.0，95%置信区间1.4 - 17.3），且在设有独立浴室的受试者中也更为常见（3.3，1.3 - 8.3）。溃疡性结肠炎与婴儿期家庭设施无明显关联。这些发现或许可以解释为何在过去50年里，发达国家克罗恩病的发病率有所上升。
