Giannoudaki Eirini, Gargan Siobhan, Hussey Seamus, Long Aideen, Walsh Patrick T
National Children's Research Center, Children's Health Ireland (CHI) Crumlin, Dublin, Ireland.
Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Front Pediatr. 2021 Mar 18;9:640497. doi: 10.3389/fped.2021.640497. eCollection 2021.
T cell subsets are considered central orchestrators of inflammation and homeostasis in the intestine and are established targets for the treatment of inflammatory bowel disease. While approaches aimed at the neutralization of T cell effector cytokines have provided significant benefits for pediatric and adult patients, more recent strategies aimed at inhibiting the infiltration of pathogenic T cell subsets have also emerged. In this review, we describe current knowledge surrounding the function of T cell subsets in pediatric inflammatory bowel disease and outline approaches aimed at targeting T cell trafficking to the intestine which may represent a new treatment option for pediatric inflammatory bowel disease.
T细胞亚群被认为是肠道炎症和内环境稳态的核心调节者，也是治疗炎症性肠病的既定靶点。虽然旨在中和T细胞效应细胞因子的方法已为儿科和成年患者带来显著益处，但最近旨在抑制致病性T细胞亚群浸润的策略也已出现。在本综述中，我们描述了目前关于儿科炎症性肠病中T细胞亚群功能的知识，并概述了旨在靶向T细胞向肠道迁移的方法，这可能代表了儿科炎症性肠病的一种新治疗选择。
