母体表皮生长因子（EGF）的改变会影响睾丸下降和附睾发育。

Alterations in maternal epidermal growth factor (EGF) effect testicular descent and epididymal development.

作者信息

Cain M P, Kramer S A, Tindall D J, Husmann D A

机构信息

Department of Urology, Mayo Clinic, Rochester, Minnesota.

出版信息

Urology. 1994 Mar;43(3):375-8. doi: 10.1016/0090-4295(94)90083-3.

DOI:10.1016/0090-4295(94)90083-3

PMID:7907827

Abstract

OBJECTIVE

(1) To determine the ability of epidermal growth factor (EGF) to reverse antiandrogen-induced cryptorchidism and epididymal abnormalities; (2) to evaluate whether alterations in maternal EGF would result in abnormal testicular descent or mal development of the epididymis.

METHODS

Experiment 1: Timed pregnant ICR mice were treated with either flutamide, flutamide plus EGF, or vehicle alone on gestational days 11 through birth. Experiment 2: Maternal EGF was abolished by removing the submandibular glands. Following timed mating, dams were treated with either flutamide, anti-EGF, DHT, or vehicle alone on gestational days 11 through birth.

RESULTS

Experiment 1: Treatment with flutamide resulted in a 36 percent (26/72) incidence of undescended testes (UDT), and a 43 percent (31/72) incidence of abnormal epididymides. Rats treated simultaneously with flutamide plus EGF had a reduced incidence of UDT (14%, 6/42) and epididymal anomalies (19%, 8/42); p < 0.01. Experiment 2: The absence of maternal EGF resulted in a significant incidence of cryptorchidism in 11/50 (22%) testes, and epididymal anomalies in 19/50 (38%); p < 0.01.

CONCLUSIONS

Our findings suggest that EGF stabilizes the wolffian duct system and partially mediates testicular descent.

摘要

目的

（1）确定表皮生长因子（EGF）逆转抗雄激素诱导的隐睾症和附睾异常的能力；（2）评估母体EGF的改变是否会导致睾丸下降异常或附睾发育不良。

方法

实验1：在妊娠第11天至出生期间，对定时受孕的ICR小鼠分别给予氟他胺、氟他胺加EGF或单独给予赋形剂。实验2：通过摘除下颌下腺消除母体EGF。定时交配后，在妊娠第11天至出生期间，对母鼠分别给予氟他胺、抗EGF、双氢睾酮或单独给予赋形剂。

结果

实验1：氟他胺治疗导致隐睾发生率为36%（26/72），附睾异常发生率为43%（31/72）。同时接受氟他胺加EGF治疗的大鼠隐睾发生率降低（14%，6/42），附睾异常发生率降低（19%，8/42）；p<0.01。实验2：母体EGF缺失导致11/50（22%）的睾丸发生隐睾症，19/50（38%）的附睾出现异常；p<0.01。