Werry J S
Department of Psychiatry and Behavioural Science, University of Auckland, New Zealand.
Acta Paedopsychiatr. 1993;56(2):113-8.
This paper is part of a special section on 'psychopharmacotherapy in children' and deals with facts, controversies and the future of the long-term use of pharmacotherapy in child and adolescent psychiatric disorders. This topic has been little studied because of career disincentives and practical difficulties. Indications for long-term use require evidence of short-term efficacy and safety, a chronic or recurring disorder and continuing proof of effect. Early onset of disorders usually found in adults, such as schizophrenia and bipolar mood disorder, form the clearest indications; but among the child disorders, attention deficit disorder has the most supporting evidence, though medication appears to have little effect on long-term outcome. There is need for further research.
本文是关于“儿童心理药物治疗”的一个特别板块的一部分，探讨了儿童和青少年精神疾病长期药物治疗的事实、争议及未来。由于职业发展的阻碍和实际困难，这个话题鲜少被研究。长期用药的指征需要有短期疗效和安全性的证据、慢性或复发性疾病以及持续有效的证明。通常在成人中出现的疾病如精神分裂症和双相情感障碍的早期发作，构成了最明确的指征；但在儿童疾病中，注意力缺陷障碍有最多的支持证据，尽管药物治疗似乎对长期预后影响不大。仍需要进一步的研究。
