β-环糊精与阿尔茨海默病淀粉样β-A4肽相互作用。
beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.
作者信息
Camilleri P, Haskins N J, Howlett D R
机构信息
Departments of Analytical Science, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Herts, UK.
出版信息
FEBS Lett. 1994 Mar 21;341(2-3):256-8. doi: 10.1016/0014-5793(94)80467-2.
PMID:7907994
Abstract
Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid beta-amyloid peptide (beta 1-40) interacts with the cyclic oligosaccharide beta-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of beta 1-40 in a cell line.
摘要
电喷雾电离质谱法已被用于证明合成的40个氨基酸的β-淀粉样肽（β1-40）与环状寡糖β-环糊精相互作用。据推测，这种与肽上疏水芳香基团的相互作用已被证明能显著降低β1-40在细胞系中的神经毒性作用。
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