慢性肝损伤营养模型对大鼠肝脏吗啡葡萄糖醛酸化的影响。

The effect of a nutritional model of chronic liver injury on the hepatic glucuronidation of morphine in rats.

作者信息

Callaghan R, Desmond P V, Mashford M L

机构信息

Department of Clinical Pharmacology, St Vincent's Hospital, Fitzroy, Victoria, Australia.

出版信息

J Pharm Pharmacol. 1993 Nov;45(11):998-9. doi: 10.1111/j.2042-7158.1993.tb05646.x.

DOI:10.1111/j.2042-7158.1993.tb05646.x

PMID:7908047

Abstract

The effect of a choline-deficient diet on the hepatic glucuronidation of morphine was investigated using a rat perfused liver system. Rats fed a choline-deficient diet developed a fatty liver with minimal necrosis. Despite the morphological changes, neither hepatic extraction ratio (0.51 +/- 0.02 in control; 0.45 +/- 0.04 in the choline-deficient rats) nor intrinsic clearance (0.85 +/- 0.05 in control; 0.77 +/- 0.09 in choline-deficient rats) were affected by this injury model. This finding suggests that glucuronidation is relatively resistant to this chronic liver injury.

摘要

使用大鼠肝脏灌注系统研究了胆碱缺乏饮食对吗啡肝脏葡萄糖醛酸化的影响。喂食胆碱缺乏饮食的大鼠出现了脂肪肝，坏死程度最小。尽管有形态学变化，但该损伤模型对肝脏提取率（对照组为0.51±0.02；胆碱缺乏大鼠为0.45±0.04）和内在清除率（对照组为0.85±0.05；胆碱缺乏大鼠为0.77±0.09）均无影响。这一发现表明，葡萄糖醛酸化对这种慢性肝损伤具有相对抗性。