Mott M G, Boyse J, Hewitt M, Radford M
Institute of Child Health, Royal Hospital for Sick Children, Bristol, UK.
Lancet. 1994 Apr 2;343(8901):828-9. doi: 10.1016/s0140-6736(94)92027-3.
Childhood Hodgkin's disease has a high cure rate but second cancers are common, related to treatment and perhaps genetic predisposition. The glycophorin A (GPA) mutation assay measures the frequency of NO and NN mutant erythrocytes of MN blood-group heterozygous individuals. Mutant frequencies in Hodgkin's disease patients were compared with controls. No significant difference from controls was found pretreatment or in patients treated with radiotherapy only. Patients who received chemotherapy had a significantly increased frequency (total mutation frequency per 10(6) cells: 31 vs 11, p < 0.001), which may be relevant to their known increased risk of secondary leukaemia.
儿童霍奇金病治愈率很高，但第二肿瘤很常见，这与治疗以及可能的遗传易感性有关。血型糖蛋白A（GPA）突变检测可测量MN血型杂合个体中NO和NN突变红细胞的频率。将霍奇金病患者的突变频率与对照组进行比较。在预处理时或仅接受放疗的患者中未发现与对照组有显著差异。接受化疗的患者突变频率显著增加（每10⁶个细胞的总突变频率：31比11，p<0.001），这可能与他们已知的继发性白血病风险增加有关。
