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[抗Thy-1单克隆抗体延长小鼠皮肤同种异体移植存活时间]

[Prolongation of survival of skin allograft with anti-Thy-1 monoclonal antibody in mice].

作者信息

Jia Z S

机构信息

Department of Laboratory, Lanzhou General Hospital, PLA.

出版信息

Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1993 Sep;9(5):376-8, 398-9.

PMID:7908251
Abstract

Skin allograft rejection is mainly mediated by T lymphocytes. We investigated the cytotoxicity of anti-Thy-1 McAb to murine thymocytes in vitro, and evaluated the prolonging effect on the survival of murine skin allografts (BALB/c--C57BL/6) in vivo with the McAb. The results showed murine thymocytes were destroyed in vitro by the McAb with complement; the survival of skin allograft was prolonged in vivo with the McAb. Lymphocyte infiltration in skin allografts was inhibited. These results provide a valuable reference for the clinical usefulness of anti-CD3 McAb in prolonging survival of human skin allografts in burn patients.

摘要

同种异体皮肤移植排斥主要由T淋巴细胞介导。我们在体外研究了抗Thy-1单克隆抗体对小鼠胸腺细胞的细胞毒性，并在体内评估了该单克隆抗体对小鼠同种异体皮肤移植（BALB/c→C57BL/6）存活的延长作用。结果显示，该单克隆抗体在体外可借助补体破坏小鼠胸腺细胞；在体内，该单克隆抗体可延长同种异体皮肤移植的存活时间。同种异体皮肤移植中的淋巴细胞浸润受到抑制。这些结果为抗CD3单克隆抗体在延长烧伤患者同种异体皮肤移植存活时间方面的临床应用提供了有价值的参考。

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1
[Prolongation of survival of skin allograft with anti-Thy-1 monoclonal antibody in mice].[抗Thy-1单克隆抗体延长小鼠皮肤同种异体移植存活时间]
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