Martin M, Merle M, Labouesse J, Canioni P
Institut de Biochimie Cellulaire du CNRS, Université de Bordeaux II, France.
J Neurosci Res. 1994 Jan;37(1):103-7. doi: 10.1002/jnr.490370114.
We examined the evolution of 1H-NMR detectable metabolites in rat cerebellum from the postnatal day 1-25, a period associated with intense metabolic changes as well as physiological and morphological modifications. The unexpected result reported here is the existence of a high concentration of acetate in neonatal rat cerebellum, progressively decreasing with age and maturation. In contrast, the cerebellum content of various metabolites such as N-acetyl-L-aspartate (NAA), glutamate, and aspartate increases from the first day onward.
我们研究了出生后第1天至25天大鼠小脑1H-NMR可检测代谢物的演变，这一时期伴随着强烈的代谢变化以及生理和形态学改变。此处报道的意外结果是新生大鼠小脑中存在高浓度的乙酸盐，其随着年龄和成熟度的增加而逐渐降低。相比之下，各种代谢物如N-乙酰-L-天冬氨酸（NAA）、谷氨酸和天冬氨酸的小脑含量从第一天起就增加。
