Imai F, Suzuki T, Ishibashi T, Ohno S, Tanaka M, Dohi Y
Second Department of Internal Medicine, Saitama Medical School.
Arerugi. 1994 Jan;43(1):68-70.
Steroid therapy has been used in patients with Sjögren's syndrome and hyperviscosity syndrome due to hypergammaglobulinemia. We report here the use of sulfasalazine therapy on patients with Sjögren's syndrome and serum immunoglobulin G levels of more than 3000 mg/dl. Sulfasalazine was used because of its inhibitory effect on B cells. Serum levels of immunoglobulin G and A were decreased after 8 weeks' administration of 1000 mg/day sulfasalazine. However four of the eleven patients experienced a side effect (skin rash). Sulfasalazine therapy could be used continuously and appeared to be an effective therapy.
类固醇疗法已用于患有干燥综合征和因高球蛋白血症导致的高黏滞综合征的患者。我们在此报告对血清免疫球蛋白G水平超过3000mg/dl的干燥综合征患者使用柳氮磺胺吡啶疗法的情况。使用柳氮磺胺吡啶是因为其对B细胞有抑制作用。在每天服用1000mg柳氮磺胺吡啶8周后，免疫球蛋白G和A的血清水平下降。然而，11名患者中有4名出现了副作用（皮疹）。柳氮磺胺吡啶疗法可以持续使用，似乎是一种有效的治疗方法。
