Cheung Y F, Lee C W, Chan C F, Chan K L, Lau Y L, Yeung C Y
University Paediatric Unit, Queen Mary Hospital, University of Hong Kong.
Med Pediatr Oncol. 1994;22(6):421-4. doi: 10.1002/mpo.2950220614.
L-Asparaginase-induced pancreatitis is an uncommon but potentially lethal complication. An 8-year-old girl with acute lymphoblastic leukaemia developed acute pancreatitis following treatment with asparaginase. Clinical and laboratory improvements were evident after treatment with somatostatin, with no complications of pancreatitis. Induction therapy for the leukaemia was able to be continued and complete remission was documented during the course of pancreatitis and somatostatin treatment, suggesting a beneficial role of somatostatin in the management of asparaginase-induced pancreatitis.
左旋门冬酰胺酶诱导的胰腺炎是一种罕见但可能致命的并发症。一名8岁急性淋巴细胞白血病女孩在接受左旋门冬酰胺酶治疗后发生了急性胰腺炎。使用生长抑素治疗后临床和实验室指标明显改善，且未出现胰腺炎并发症。白血病的诱导治疗得以继续，在胰腺炎和生长抑素治疗过程中记录到完全缓解，这表明生长抑素在左旋门冬酰胺酶诱导的胰腺炎管理中具有有益作用。
