蛋白质营养不良对大鼠乙酰水杨酸致畸性的影响。

Influence of protein malnutrition on teratogenicity of acetylsalicylic acid in rats.

作者信息

Hamed M R, al-Assy Y S, Ezzeldin E

机构信息

National Organization for Drug Control and Research, Cairo, Egypt.

出版信息

Hum Exp Toxicol. 1994 Feb;13(2):83-8. doi: 10.1177/096032719401300204.

DOI:10.1177/096032719401300204

PMID:7908815

Abstract

The effect of protein malnutrition (PM) on the embryotoxicity and teratogenicity of aspirin in rats has been studied. Protein malnourishment was produced from Days 7 to 21 of gestation by limiting the casein content of the diet to 5% in comparison to 20% for the normal animals. Six dose levels of aspirin (50-175 mg kg-1) were administered p.o. from Days 8 to 11 of pregnancy. Aspirin from 75 mg kg-1 d-1 induced growth retardation, embryolethality and teratogenicity, as shown by external, skeletal and visceral malformations. All these effects were potentiated by protein malnutrition.

摘要

研究了蛋白质营养不良（PM）对大鼠胚胎毒性和致畸性的影响。在妊娠第7天至21天，通过将饮食中的酪蛋白含量限制在5%（正常动物为20%）来造成蛋白质营养不良。在妊娠第8天至11天，经口给予六个剂量水平的阿司匹林（50 - 175毫克/千克）。从75毫克/千克/天起，阿司匹林就会导致生长迟缓、胚胎死亡和致畸性，表现为外部、骨骼和内脏畸形。所有这些影响都因蛋白质营养不良而增强。