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[儿茶酚胺诱导的室性心动过速:青少年严重晕厥的一个原因]

[Catecholamine induced ventricular tachycardia: a cause of severe syncope during adolescence].

作者信息

Lévy M, Villain E, Philippe F, Kachaner J

机构信息

Département de pédiatrie, hôpital Necker/Enfants-Malades, Paris, France.

出版信息

Pediatrie. 1993;48(7-8):533-5.

PMID:7909369
Abstract

A 15-year-old female teenager had recurrent syncopes and had been unsuccessfully treated for 6 years for seizures and hysteria. Syncopes were always triggered by emotions, or efforts, but electrocardiograms were normal between the episodes. A 24-hour-monitoring during a syncope, and provocative tests (exercise testing and isoprenaline administration) showed severe ventricular arrhythmias with premature polymorphous beats, followed by ventricular tachycardia and then ventricular fibrillation. These "catecholamine-induced" ventricular tachycardias are very rare but are always fatal without treatment. Syncopes are stress-induced and the diagnosis is almost always delayed, because the patients have a normal electrocardiogram, with normal QT interval. The arrhythmia appears beyond a "threshold" sinus rate and is easily reproducible by exercise testing. Betablockers are the only efficient treatment to prevent sudden death.

摘要

一名15岁的女性青少年反复出现晕厥,因癫痫和癔症接受了6年的治疗但均未成功。晕厥总是由情绪或用力诱发,但发作间期心电图正常。在一次晕厥期间进行的24小时监测以及激发试验(运动试验和注射异丙肾上腺素)显示,存在严重的室性心律失常,伴有多形性早搏,随后是室性心动过速,进而发展为心室颤动。这些“儿茶酚胺诱导的”室性心动过速非常罕见,但未经治疗往往会致命。晕厥是由压力诱发的,而且诊断几乎总是延迟,因为患者的心电图正常,QT间期也正常。心律失常出现在“阈值”窦性心率之上,且通过运动试验很容易再现。β受体阻滞剂是预防猝死的唯一有效治疗方法。

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