Gazzinelli R T, Denkers E Y, Sher A
Immunology and Cell Biology Section, NIAID, National Institutes of Health, Bethesda, MD 20892.
Infect Agents Dis. 1993 Jun;2(3):139-49.
Cell-mediated immunity (CMI) provides a major host defense against infectious disease and malignancy. Nevertheless, the mechanisms underlying the induction of CMI remain poorly understood and this lack of knowledge remains an important impasse in the design of rationally based vaccines and immunotherapies. Toxoplasma gondii is an intracellular pathogen that, as part of its normal life cycle, induces a potent CMI response leading to host resistance. Studies on the interaction of this parasite with the immune system therefore provide a unique approach for identifying events that selectively lead to the triggering of host-protective CMI. In addition, this knowledge may provide new strategies for immunotherapy of opportunistic infections in immunodeficient hosts.
细胞介导免疫（CMI）是宿主抵御传染病和恶性肿瘤的主要防御机制。然而，CMI诱导的潜在机制仍知之甚少，这一知识空白仍是合理设计疫苗和免疫疗法的重要障碍。刚地弓形虫是一种细胞内病原体，在其正常生命周期中，它会诱导强烈的CMI反应，从而导致宿主产生抵抗力。因此，对这种寄生虫与免疫系统相互作用的研究为识别选择性引发宿主保护性CMI的事件提供了独特的方法。此外，这一知识可能为免疫缺陷宿主的机会性感染免疫治疗提供新策略。
