HIV阳性患者中系统性β-干扰素和胸腺刺激素治疗人乳头瘤病毒外阴-会阴感染

Management of human papilloma virus vulvo-perineal infection with systemic beta-interferon and thymostimulin in HIV-positive patients.

作者信息

Frega A, di Renzi F, Stentella P, Pachì A

机构信息

II Clinic of Obstetrics and Gynecology, University of Rome La Sapienza, Italy.

出版信息

Int J Gynaecol Obstet. 1994 Mar;44(3):255-8. doi: 10.1016/0020-7292(94)90175-9.

DOI:10.1016/0020-7292(94)90175-9

PMID:7909764

Abstract

OBJECTIVES

To evaluate the effect of a combined therapy based on beta-interferon and thymostimulin in HIV-seropositive women with florid vulvoperineal condylomatosis.

METHODS

Nineteen HIV-seropositive women affected by HPV florid vulvo-perineal infection were studied. Their ages ranged from 19 to 32 years (mean = 26); all were smokers; 11 (57.89%) were intravenous drug users with a mean period of drug addiction of 5 years. No patient was on AZT therapy. All patients underwent a combined medical therapy based on beta-interferon administration with doses of 3,000,000 IU i.m. daily for 7 days and subsequently on alternate days for 2 weeks associated with the administration of 70 mg i.m. of thymostimulin per day on alternate days for 30 days.

RESULTS

Seven (36.84%) patients showed complete recovery at the end of follow-up; 5 (26.31%) patients showed partial recovery and 7 (36.84%) did not respond to therapy.

CONCLUSION

A pro-host immunotherapy seems to be indicated in patients affected by immunodeficiency syndrome.

摘要

目的

评估基于β-干扰素和胸腺刺激素的联合疗法对患有严重外阴尖锐湿疣的HIV血清阳性女性的疗效。

方法

对19名受HPV严重外阴-会阴感染影响的HIV血清阳性女性进行了研究。她们的年龄在19至32岁之间（平均26岁）；均为吸烟者；11名（57.89%）为静脉吸毒者，平均吸毒时间为5年。无患者接受齐多夫定治疗。所有患者均接受了联合药物治疗，即每天肌肉注射300万国际单位的β-干扰素，连续7天，随后隔日注射2周，并隔日肌肉注射70毫克胸腺刺激素，共30天。