Mangiameli A, Brogna A, Catanzaro R, Sofia M, Blasi A
Istituto di Medicina Interna A. Francaviglia, Università degli Studi di Catania.
Clin Ter. 1994 Feb;144(2):107-14.
Levosulpiride, a dopaminergic antagonist was compared in a double-blind randomized study with domperidone for treatment of functional dyspepsia in 50 patients divided into two groups of 25 subjects each. Group I received 25 mg levosulpiride 3 times daily, group II received 10 mg domperidone 3 times daily, all for 30 days. Periodic clinical examination at days 0, 7, 15, 30 showed symptomatic changes. Gallbladder and gastric emptying was studied by ultrasonography at the start and end of treatment. Both drugs had a positive influence on dyspeptic symptoms and on gastric and gallbladder emptying, but the latter parameters were improved significantly more effectively by levosulpiride. As to tolerability, there have been 3 drop-outs and a further 6 patients complained of sides effects that did not require suspension of treatment.
左旋舒必利是一种多巴胺能拮抗剂，在一项双盲随机研究中，将其与多潘立酮用于治疗功能性消化不良进行比较。50例患者被分为两组，每组25例。第一组患者每日3次服用25毫克左旋舒必利，第二组患者每日3次服用10毫克多潘立酮，疗程均为30天。在第0、7、15、30天进行定期临床检查，观察症状变化。在治疗开始和结束时，通过超声检查研究胆囊和胃排空情况。两种药物对消化不良症状以及胃和胆囊排空均有积极影响，但左旋舒必利对后两项指标的改善更为显著。在耐受性方面，有3例患者退出研究，另有6例患者抱怨出现副作用，但这些副作用并不需要停止治疗。
