免疫复合物p24抗原：人类免疫缺陷病毒感染中的一种新的预后标志物。
Immune complex p24 antigen: a new prognostic marker in human immunodeficiency virus infection.
作者信息
Cabezas T, Quirós E, Garcia F, Hernández-Quero J, Bernal M C, Martinez M A, de la Higuera J, Piédrola G, Maroto M C
机构信息
Microbiology Service, University of Granada Hospital, Spain.
出版信息
Infection. 1994 Jan-Feb;22(1):4-7. doi: 10.1007/BF01780756.
p24 antigen (p24 Ag) is usually not found in patients in the asymptomatic phase of HIV infection, mainly because it is bound to anti-p24 antibodies (p24 Ab), with which it forms immune complexes. Nine asymptomatic patients positive for HIV-1 antibodies (stage II CDC criteria) treated with r alpha-interferon were followed (7.5 +/- 0.5 months), and a basal and final sample were tested for p24 Ag immune complexes (p24 Ag-IC), free p24 Ag, p24 Ab, CD4 count, beta 2-microglobulin, properdin B factor, and C3 and C4 complement fractions. p24 Ag-IC was detected in 55.5% of the samples, whereas free p24 Ag was detected in 5.5%. The finding of no change or an increase in p24 Ag-IC serum levels may be considered a prognostic marker. We believe that p24 Ab cannot be used as a prognostic marker unless p24 Ag-IC detection is simultaneously evaluated.
p24抗原（p24 Ag）在HIV感染无症状期患者中通常检测不到，主要是因为它与抗p24抗体（p24 Ab）结合，形成免疫复合物。对9例符合美国疾病控制与预防中心（CDC）II期标准的HIV-1抗体阳性无症状患者进行了rα干扰素治疗并随访（7.5±0.5个月），检测了基础样本和最终样本中的p24 Ag免疫复合物（p24 Ag-IC）、游离p24 Ag、p24 Ab、CD4计数、β2微球蛋白、备解素B因子以及C3和C4补体成分。55.5%的样本检测到p24 Ag-IC，而5.5%的样本检测到游离p24 Ag。p24 Ag-IC血清水平无变化或升高这一发现可被视为预后标志物。我们认为，除非同时评估p24 Ag-IC检测结果，否则p24 Ab不能用作预后标志物。
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