钴可阻断麻醉大鼠孤束核中由L-谷氨酸诱导的呼吸暂停和动脉低血压。

Cobalt blocks L-glutamate-induced apnea and arterial hypotension in the nucleus tractus solitarii of anaesthetized rats.

作者信息

Vitagliano S, Berrino L, Pizzirusso A, Lampa E, Rossi F

机构信息

Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, II University of Naples, Italy.

出版信息

Neuropharmacology. 1994 Jan;33(1):145-6. doi: 10.1016/0028-3908(94)90110-4.

DOI:10.1016/0028-3908(94)90110-4

PMID:7910384

Abstract

The local application of cobalt reversibly blocks calcium-channel conductance and therefore synaptic transmission. In this study pretreatment with a solution of cobalt (100 mM) in the nucleus tractus solitarii (NTS) of anaesthetized rats significantly blocked the apnea (P < 0.01) and arterial hypotension induced by L-glutamate (25 mM) and N-methyl-D-aspartate (0.4 mM) microinjected in the NTS. We conclude that cobalt causes these effects by acting at the postsynaptic level.

摘要

钴的局部应用可逆性地阻断钙通道电导，从而阻断突触传递。在本研究中，用钴溶液（100 mM）预处理麻醉大鼠的孤束核（NTS），可显著阻断由向NTS微量注射L-谷氨酸（25 mM）和N-甲基-D-天冬氨酸（0.4 mM）所诱导的呼吸暂停（P < 0.01）和动脉低血压。我们得出结论，钴通过作用于突触后水平产生这些效应。