Sullivan T J, Reese J H, Jauregui L, Miller K, Levine L, Bachmann K A
Center for Applied Pharmacology, University of Toledo College of Pharmacy, Ohio 43606.
Aliment Pharmacol Ther. 1994 Feb;8(1):123-6. doi: 10.1111/j.1365-2036.1994.tb00168.x.
The influence of concomitant antacid administration on the relative bioavailability of the H2-receptor antagonists cimetidine, famotidine, nizatidine and ranitidine, was investigated in a panel of 21 healthy, adult male volunteers in an eight-way crossover trial. Administration with antacid reduced the bioavailability of all agents tested. The reduction in area under the serum concentration-time curve (AUC) was greatest for cimetidine (23%) and ranitidine (26%) and least for nizatidine (12%) and famotidine (19%). Reductions in peak serum concentration (Cmax) followed a similar pattern. The times of peak serum concentrations were not affected by antacid. Comparison of the relative bioavailability among all drugs tested showed no statistically significant differences in the effect of antacid administration on these agents. However, a high degree of intersubject variability was observed.
