Mitchell R J, Earl L, Bisucci T, Gasiamis H, Williams J
Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria Australia.
Hum Hered. 1994 Mar-Apr;44(2):77-84. doi: 10.1159/000154195.
The distribution of two common TaqI restriction fragment length polymorphisms (RFLPs) of the cholesteryl ester transfer protein (CETP) gene were determined in 271 Italian-born and 170 Greek-born migrants to Melbourne, Australia. A much smaller number were examined for the EcoNI RFLP of the same gene. Allele frequencies of the TaqI A RFLP exhibited the least variation in both ethnic groups, and no significant regional heterogeneity in allele or genotype frequencies of either TaqI RFLP was detected for Greece or Italy. There was no difference between Italians and Greeks for the TaqI A polymorphism and the variability at the B RFLP was of borderline significance. Comparisons with other Caucasian populations revealed that allele frequencies of all three CETP RFLPs are remarkably uniform within Caucasians, with the TaqI B polymorphism being the most variable.
在271名出生于意大利、170名出生于希腊并移民至澳大利亚墨尔本的人群中，对胆固醇酯转运蛋白（CETP）基因的两种常见TaqI限制性片段长度多态性（RFLP）的分布情况进行了测定。对相同基因的EcoNI RFLP检测的人数则少得多。TaqI A RFLP的等位基因频率在两个种族群体中表现出最小的变异性，并且在希腊或意大利，未检测到两种TaqI RFLP的等位基因或基因型频率存在显著的区域异质性。意大利人和希腊人在TaqI A多态性方面没有差异，而B RFLP的变异性具有临界显著性。与其他高加索人群的比较显示，所有三种CETP RFLP的等位基因频率在高加索人群中非常一致，其中TaqI B多态性的变异性最大。
