Schellenberg R, Milch W, Schwarz A, Schober F, Dimpfel W
Pro Science Private Research Institute GmbH, Linden, Germany.
Int Clin Psychopharmacol. 1994 Spring;9(1):17-24. doi: 10.1097/00004850-199400910-00003.
Approximately one-third of schizophrenic patients receiving antipsychotic drugs obtain little or no benefit from them. In some reports, response has been linked with "prognostic" factors, including abnormal EEG and drug response (pharmaco-EEG). Measurements of topological EEG spectral power and Brief Psychiatric Rating Scale (BPRS) values were obtained in 15 schizophrenics over a period of 20 min immediately after the first application, and at weekly intervals after single intramuscular injection of 2 ml depot haloperidol (Haldol-Decanoate). A highly significant increase in the alpha-1 power density at almost all positions and an increase in theta power at parietotemporal regions can be described as electrophysiological parameters of the acute pharmaco-EEG. BPRS values decreased continuously within the first 2 weeks followed by an increase to the predrug level after the fourth week. Over the whole observation period there was a correlation between neurophysiological data (alpha-1 power) and clinical symptomatology (BPRS total score; r = -0.7). Therefore, it can be concluded that quantitative EEG recordings are able to serve as a tool for the optimization of the depot neuroleptic treatment in schizophrenics.
大约三分之一接受抗精神病药物治疗的精神分裂症患者从这些药物中获益甚微或毫无益处。在一些报告中，疗效与“预后”因素有关，包括异常脑电图和药物反应（药物脑电图）。对15名精神分裂症患者在首次注射2毫升长效氟哌啶醇（癸酸氟哌啶醇）后立即进行20分钟的测量，并在每周一次肌肉注射后，测量其脑电图拓扑频谱功率和简明精神病评定量表（BPRS）值。几乎所有部位的α-1功率密度显著增加，顶颞区的θ功率增加，可描述为急性药物脑电图的电生理参数。BPRS值在最初2周内持续下降，随后在第4周后回升至用药前水平。在整个观察期内，神经生理数据（α-1功率）与临床症状（BPRS总分；r = -0.7）之间存在相关性。因此，可以得出结论，定量脑电图记录能够作为优化精神分裂症患者长效抗精神病药物治疗的一种工具。
