Upcroft P
Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia.
Acta Trop. 1994 Mar;56(2-3):195-212. doi: 10.1016/0001-706x(94)90063-9.
Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in drug efflux have been compared with their mammalian counterparts. Possible mechanisms and models for drug efflux have been considered. The unusual and extensive range of substrates transported by the ATP-binding cassette (ABC) family of transporters which includes the MDRs has been raised. The impact of kinetics, structure and bioenergetics of the MDR family members on mechanisms of transport has been accentuated to argue that MDR efflux considered in isolation appears bizarre but may be better understood in a broader context.
已对经过充分研究的致病原生动物中的多重耐药性（MDR）现象的证据进行了研究。这已被置于更熟悉的MDR外排转运蛋白和哺乳动物细胞克隆的mdr基因的背景下。已将原生动物中mdr基因家族的同源物及其在药物外排中的可能作用与其哺乳动物对应物进行了比较。已考虑了药物外排的可能机制和模型。包括MDR在内的ATP结合盒（ABC）转运蛋白家族所转运底物的异常广泛范围已被提及。MDR家族成员的动力学、结构和生物能量学对转运机制的影响已得到强调，以论证孤立地考虑MDR外排似乎很奇怪，但在更广泛的背景下可能会有更好的理解。
